Urinal®
PREVENTION of Urinary tract infection for LONG TERM USAGE
Urinal® contains a unique combination of cranberry substances - NutriCran®, Vaccinium macrocarpon (cranberry) dried juice concentrate extract, and CystiCran®, highly- concentrated Vaccinium macrocarpon extract, and newly also extract of Solidago virgaurea (Goldenrod) and Vitamin D. In vitro testing has demonstrated the anti-adherence e ect of urine on uropathogenic bacteria after consumption of cranberry products. Cranberries are a rich source of bioflavonoids, phenolic compounds and other natural substances.
The amount of cranberry extracts in the maximum daily dose (3 capsules) corresponds to at least 57 300 mg of cranberry fruit. Solidago virgaurea contributes to the normal function of the bladder and lower urinary tract and helps maintain a healthy urinary tract. Vitamin D supports the normal function of the immune system. Urinal® can be used along with antibiotics.
Effects:
- In vitro anti-adherence e ect of urine
on uropathogenic bacteria after consumption of cranberry products - Goldenrod contributes to normal urinary elimination functions
- Goldenrod helps to maintain a healthy bladder and lower urinary tract
- Vitamin D supports the normal function of the immune system
URINAL® = Each soft gelatinous capsule contains a unique combination of cranberry substances: NutriCran®: Cranberries (Vaccinium macrocarpon) dried juice concentrate extract: 200 mg. CystiCran®: Cranberries (Vaccinium macrocarpon) highly concentrated cranberry extract: 3 mg.
Anti-in ammatory e ect during the in ammatory processes [16]
• URINAL® (cranberry) Inhibit pro-in ammatory cytokine and chemokine expression in adipocytes, reducing the in ammatory process induced via oxidative stress in adipose tissue[16].
• Preventive e ects of URINAL® (CRANBERRY) on induced experimental colitis[17] with a current report suggests that cranberries can be used to prevent and reduce the symptoms of irritable bowel syndrome(IBS)[17].
For the intra-abdominal infections
• Anti-invasive activity [12].
• A study results revealed that cranberry alone reduced extra-intestinal pathogenic E. coli (ExPEC) invasion by 80.8% relative to control by increasing ExPEC agglutination and decreasing ExPEC invasion of epithelial cells[12].
• In conjunction with antibiotic treatment bene cial in eradicating Helicobacter pylori infections[22].
• Two-week consumption of cranberry reduces the overall numbers of E. coli in the intestines without a ecting intestinal ora & normal commensal bacteria [5].
For the respiratory tract infections
Consumption of URINAL® signi cantly enhances human -T cell function & proliferation in the epithelium rst line of defense and reduces the number of symptoms associated with colds and in uenza [6] [7].
In general
- Synergy between the antibiotic and the cranberry compound in killing the bacteria [10].
- URINAL® interferes with bacterial virulence mechanisms [4].
- Anti-bio lm properties of cranberry URINAL® against pathogenic bacteria [3] [21] [22].
- Proved Antiviral activity (against Herpes simplex virus HSV 1 & 2 and cold & u viruses) [28].
is one of the leading & biggest vitamin and food supplement manufacturer and marketer in the
European Union markets with the brand and product portfolio contains over a hundred o erings & exports its products to Europe, middle East, Asia and Africa with a rapid worldwide expansion.
is one of the companies with the fastest growth in the pharmaceutical industry from Central and Eastern Europe with purpose of promoting innovations & o ering its consumers the best choices for a healthy life.
The course of production and all connected processes take place according to given strict rules known as the GMP (Good Manufacturing Practice) & quality systems.The GMP is a part of Quality Assurance System that ensures that products are continuously processed and checked in agreement with the quality standers.
References
[ 1 ]: Howell et al. BMC Infectious Diseases 2010.
[ 2 ]: Feldman et al. BMC Complementary and Alternative Medicine 2012.
[ 3 ]: Ulrey et al. BMC Complementary and Alternative Medicine 2014.
[ 4 ]: Nutrition Journal 2006 USA.
[ 5 ]: Burleigh et al. Nutrition Journal 2013.
[ 6 ]: Nantz et al. Nutrition Journal 2013.
[ 7 ]: Lavigne et al. BMC Research Notes 2011.
[ 8 ]: Asma et al. BMC Urology (2018) - Canada.
[ 9 ]: Heitmann et al. BMC Complementary and Alternative Medicine 2013
[ 10 ]: Cranberries Pack a Punch to Bacteria Linked to Cystic Fibrosis | George Mason
[ 11 ]: Skarpańska - Stejnborn et al. Journal of the International Society of Sports Nutrition (2017) [12]:Journalof Functiona lFoods 25(2016) USA.
[ 13 ]: Molecular Metabolism Volume 6, Issue 12, December 2017, Pages 1563-1573 Canada
[ 14 ], [ 15 ], [ 16 ], [ 17 ], [ 18 ], [ 19 ], [ 20 ], [ 21 ], [ 22 ], [ 23 ], [28]: www.sciencedirect.com
[24]: www.naturalremediesforkidneystones.net/cranberry-juice-kidney-stones/
[25]: www.pcrm.org/health/healthcare-professionals/nutrition-curriculum/.
[26],[27]: www.ncbi.nlm.nih.gov/pmc/articles/